Duloxetine (Cymbalta): Uses, Dosage, Side Effects

Duloxetine (brand name Cymbalta) is an SNRI antidepressant many people use to treat major depressive disorder, generalized anxiety, nerve pain from diabetes, fibromyalgia, and chronic musculoskeletal pain. If you were prescribed duloxetine, this quick guide will help you understand what it does, how to take it, and what to watch for.

Duloxetine works by boosting levels of serotonin and norepinephrine in the brain. That helps mood and can reduce pain signals from damaged nerves. It doesn’t work instantly—most people notice benefits after 2 to 6 weeks, and full effect can take longer.

How to take duloxetine

Doctors usually start low and increase slowly. Common starting doses are 30 mg or 40 mg once daily, then moving to 60 mg for many conditions. For some types of pain or fibromyalgia, doses up to 60 mg twice daily may be used, but only under close supervision. Take it the same time each day, with or without food. Don’t crush extended‑release capsules.

If you miss a dose, take it as soon as you remember unless it’s almost time for the next dose. Don’t double up. Stopping suddenly can cause withdrawal symptoms like dizziness, nausea, irritability, or electric shock sensations—ask your provider about tapering when it’s time to stop.

Common side effects and safety tips

Expect mild side effects at first: nausea, dry mouth, tiredness, constipation, or sleep changes are common. Most ease in 1–2 weeks. More serious issues are rare but need quick action: new or worsening mood changes, suicidal thoughts (especially under 25), severe stomach pain, yellowing of the skin, or signs of serotonin syndrome (high fever, tremor, confusion, fast heartbeat).

Avoid drinking a lot of alcohol while on duloxetine. Don’t take duloxetine with MAO inhibitors, or within 14 days of stopping an MAOI—this can cause dangerous reactions. Tell your provider about all meds and supplements, especially other antidepressants, tramadol, certain migraine drugs, or St. John’s wort.

People with liver disease, heavy alcohol use, uncontrolled glaucoma, or a history of seizures need special care. Pregnant or breastfeeding? Talk to your doctor—there are risks and benefits to weigh for each case.

Simple tips: keep a medication list, report new symptoms fast, schedule follow-ups to check progress, and ask about blood pressure monitoring if you have hypertension. If cost or access is a concern, reputable Canadian pharmacies can be an option—ask your provider for safe sources.

Duloxetine can help, but it works best with clear guidance from a prescriber. If you’re unsure about side effects, interactions, or how long you’ll be on it, reach out to your healthcare team—they’re there to adjust the plan so the medicine fits your life.